How bad is my distribution really?

Most scientists think that t-tests, ANOVAs, linear regression etc rely on your data being normally distributed. Is that really true? And given that no data is perfectly normal, how normal does your data have to be? Can I see what effect non-normality will have on my hypothesis testing? I’m going to use some simply tricks that us to see how bad our distribution is.
Continue reading

Neuronal Modelling – The very basics. Part 1.

I think a lot of people are confused about neuronal modelling. I think a lot of people think it is more complex than it is. I think too many people think you have to be a mathematical or computational wizard to understand it, and I think that leads to a lot of good modelling being discounted and a lot of bad modelling being let through peer-review. I’m here to tell you that biophysical models on neurons don’t have to be hard to implement, or understand. I’m going to start you off on the ground floor, in fact, below the ground floor, this is the basement level. All you need to know is a little coding (I’m going to do both Matlab and Python to start). But I should temper your expectations. When we are done, you’re not going to be ready to publish fully fledged multi-compartment models of neurons, but at least you will understand the fundamental principles of what is happening. And the most fundamental of all is this…

\frac{\mathrm{d}v}{\mathrm{d}t} = \frac{i}{C}

Continue reading

Trying to make the worlds cheapest syringe pump/linear drive

99% of things you buy from scientific suppliers are violently overpriced. Peristaltic pumps for $2000 that only contain $50 worth of equipment. Homeothermic blankets should only cost about three fifty. But the one that has always annoyed me are syringe drivers. These are nothing more than a stepper motor, a lead screw and a bit of electronics. The budget ones tend to start at around $300, and they go up to ten times that. I’m not standing for that, and neither should you. So I wanted to make one myself.

syringe-driver

Continue reading

Shouting Into the Void: Interacting with PubMed part II

So you’ve just been accepted for publication. At this point, after months of extra experiments and back and forths with reviewers, you’re probably well and truly sick of your paper. However, the months roll by you look at the paper again, you note a cute bit of data analysis here, nice turn of phrase there, and with a gleam in your eye you look to see how many citations you’ve gotten. And unless you’re very lucky, that number might well be still in single digits. 12 months of work, and less than 10 people have ever cited your work. Maybe you feel like it was all for nothing. Well I’m here to make you feel better, because your work was much more important than that. Continue reading

Interacting with PubMed. Part I

As a scientist, your life’s work is your publication list. I like to be intimate with mine. Sometimes I just stare at it. I’d buy it a glass of wine if I could. Maybe even caress it softly. Sure, she ain’t much to look at, but she’s mine, and I want to show her off. And if you want a job, you’re going to want to show yours off too. So I’m going to show you how to scrape your publication list from Pubmed with Python. Continue reading